Services

EXPLORER
"I wanna know''

EXPLORER PLUS
"Explore more"

PATHFINDER
"Biomarker Extraordinaire"

CARTOGRAPHER
''There is no end to my curiosity"

Metabolite classes

Non-volatile

moderately hydrophilic and hydrophoblc
metabolites that include but are not limited to: bile acids and steroids
non-steroidal polar lipids (carnitines, ceramides, phospholipids, oxylipins, sphingolipids etc.)
small peptides and analogues
nucleotides and nucleosides
alkaloids
vitamins
flavonoids
polyketides
drugs and pharmaceuticals

Non-volatile

moderately hydrophilic and hydrophoblc
metabolites that include but are not limited to: bile acids and steroids
non-steroidal polar lipids (carnitines, ceramides, phospholipids, oxylipins, sphingolipids etc.)
small peptides and analogues
nucleotides and nucleosides
alkaloids
vitamins
flavonoids
polyketides
drugs and pharmaceuticals fatty acids and derivatives
primary metabolites (e.g. amino acids, small alcohols, amines, polycarboxylic acids etc.)
mono- and di-saccharides
pesticides
short-chain fatty acids (SCFAs)

Non-volatile

moderately hydrophilic and hydrophoblc metabolites that include but are not limited to: Bile acids and steroids
non-steroidal polar lipids ( carnitines, ceramides, phospholipids, oxylipins, sphingolipids etc.)
small peptides and analogues
nucleotides and nucleosides
alkaloids
vitamins
flavonoids
polyketides
drugs and pharmaceuticals fatty acids and derivatives
primary metabolites (e.g. amino acids, small alcohols, amines, polycarboxylic acids etc.)
mono- and di-saccharides
pesticides
short-chain fatty acids (SCFAs) metabolites with broad range of polarities that include but are not limited to:

broad range of lipids saccharides and polyalcohols halogenated molecules

energy metabolites ( e.g. acetyl- СоA, NADH etc.}

Non-volatile

moderately hydrophilic and hydrophoblc metabolites that include but are not limited to: Bile acids and steroids
non-steroidal polar lipids ( carnitines, ceramides, phospholipids, oxylipins, sphingolipids etc.)
small peptides and analogues
nucleotides and nucleosides
alkaloids
vitamins
flavonoids
polyketides
drugs and pharmaceuticals fatty acids and derivatives
primary metabolites (e.g. amino acids, small alcohols, amines, polycarboxylic acids etc.)
mono- and di-saccharides
pesticides
short-chain fatty acids (SCFAs) metabolites with broad range of polarities that include but are not limited to:

broad range of lipids saccharides and polyalcohols halogenated molecules

energy metabolites ( e.g. acetyl- СоA, NADH etc.}

Data Analysis

Raw data Feature tаblе List of annotations at Levels 1-3 Molecular network РСоА (if metadata provided) Publication ready methods

Raw data Feature tables for each method used List of annotations at Levels 1-3 Molecular network РСоА (if metadata provided) Publication ready methods

Raw data Feature tables for each method used List of annotations at Levels 1-3 Molecular network РСоА (if metadata provided) Statistical analysis including supervised learning and multivariate analysis Publication ready methods and codes to reproduce the analysis

Raw data Feature tables for each method used Ust of annotations at Levels 1-3 Molecular network РСоА (if metadata provided) Statistical analysis including supervised learning and multivariate analysis ln silico prediction of metaЬolites of interest* Pathway analysis Publication ready methods and codes to reproduce the analysis

Methods used

Two types LC-MS/MS in Positive and Negative ion modes. GC-MS {derivatized or non-derivatized}
Feces
Blооd serum/plasma
skin
urine
bacterial and other cultures
nucleotides
peptides
steroids
hormones
dyes
fatty
acids
alcohols

Pilot included

Not included

Included

Approximate Cost (per Sample)

$200-$300

$500

$600

$800

Additional bioinformatics analysis (see details)

Not included

Included

Multi-omics integration analysis

Not included

Included

Data Analysis

Raw data Feature tаblе List of annotations at Levels 1-3 Molecular network РСоА (if metadata provided) Publication ready methods

Metabolite classes

Non-volatile

moderately hydrophilic and hydrophoblc;
metabolites that include but are not limited to: bile acids and steroids;
non-steroidal polar lipids (carnitines, ceramides, phospholipids, oxylipins, sphingolipids etc.);
small peptides and analogues;
nucleotides and nucleosides;
alkaloids;
vitamins;
flavonoids;
polyketides;
drugs and pharmaceuticals

Methods used

Not included

Data Analysis

Raw data Feature tables for each method used List of annotations at Levels 1-3 Molecular network РСоА (if metadata provided) Publication ready methods

Metabolite classes

Non-volatile

moderately hydrophilic and hydrophoblc;
metabolites that include but are not limited to: bile acids and steroids;
non-steroidal polar lipids (carnitines, ceramides, phospholipids, oxylipins, sphingolipids etc.);
small peptides and analogues;
nucleotides and nucleosides;
alkaloids;
vitamins;
flavonoids;
polyketides;
drugs and pharmaceuticals fatty acids and derivatives;
primary metabolites (e.g. amino acids, small alcohols, amines, polycarboxylic acids etc.);
mono- and di-saccharides;
pesticides;
short-chain fatty acids (SCFAs)

Methods used

Not included

Data Analysis

Metabolite classes

Non-volatile

moderately hydrophilic and hydrophoblc metabolites that include but are not limited to: Bile acids and steroids
non-steroidal polar lipids ( carnitines, ceramides, phospholipids, oxylipins, sphingolipids etc.);
small peptides and analogues;
nucleotides and nucleosides;
alkaloids;
vitamins;
flavonoids;
polyketides;
drugs and pharmaceuticals fatty acids and derivatives;
primary metabolites (e.g. amino acids, small alcohols, amines, polycarboxylic acids etc.);
mono- and di-saccharides;
pesticides;
short-chain fatty acids (SCFAs) metabolites with broad range of polarities that include but are not limited to:

Methods used

Included

Data Analysis

Metabolite classes

Non-volatile

moderately hydrophilic and hydrophoblc metabolites that include but are not limited to: Bile acids and steroids
non-steroidal polar lipids ( carnitines, ceramides, phospholipids, oxylipins, sphingolipids etc.);
small peptides and analogues;
nucleotides and nucleosides;
alkaloids;
vitamins;
flavonoids;
polyketides;
drugs and pharmaceuticals fatty acids and derivatives;
primary metabolites (e.g. amino acids, small alcohols, amines, polycarboxylic acids etc.);
mono- and di-saccharides;
pesticides;
short-chain fatty acids (SCFAs) metabolites with broad range of polarities that include but are not limited to:

Methods used

Two types LC-MS/MS in Positive and Negative ion modes. GC-MS {derivatized or non-derivatized}
Feces
Blооd serum/plasma
skin
urine
bacterial and other cultures
nucleotides
peptides
steroids
hormones
dyes
fatty
acids
alcohols

Included

Services include the following:

Extraction of molecules from provided samples with rigorous QA/QC procedures
Data acquisition using LC-MS/MS with various chromatographic approaches in Positive and Negative mode as well as GC-MS (derivatized and non-derivatized) to capture a wide range of metabolites based on the tier chosen. We use proprietary exhaustive MS/MS acquisition methods to acquire a maximum number of high quality fragmentation spectra. Targeted analysis of specific compounds of interest is available upon request.
Data analysis with following deliverables:

Annotation of known molecules to the Level 1*: up to 1250 human-related metabolites, using molecular mass, retention time, and MS/MS pattern matching (ambiguous stereochemistry)
Annotation of known molecules to the Level 2*: using molecular mass, MS/MS pattern matching to commercial and open-source spectral libraries. Usually identifies up to 10% of detected features from a particular sample type (thousands of features can be identified)
Annotations of known and novel molecules to Level 3* and 4* using propagated libraries and in silico prediction of high-quality MS/MS (can identify up to 30% of features with proposed structures and up to 80% of features with chemical class)
Principal component analysis plots with the metadata (if provided) integrated
Molecular Networks of all detected components with the overlay of all annotation levels and with incorporated metadata(if provided) for easy visualizations

Revolutionizing Biomarker Discovery with Arome Science

Explore the forefront of biomarker discovery and analysis with Arome Sciences’ pioneering semi-targeted metabolomics technology.

Our press release unveils how our unique approach seamlessly integrates multiomic data and metabolite analysis to enhance clinical development and product innovation

Explore disease, drug development, and more with Arome Sciences’ data solutions. Unlock insights and scientific breakthroughs in biomarker research.

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